top of page

Decoding the chromatin circuitry guiding stem cell fate, regeneration, and aging

2024

Flora, P., Li, M. Y., Zhou, Y., Mercédes, M., Zheng, X. Y., Galbo, P. M., Zheng, D., & Ezhkova, E. (2024). H2AK119ub dynamics controls hair follicle stem cell quiescence. bioRxiv : the preprint server for biology, 2024.10.10.617646. https://doi.org/10.1101/2024.10.10.617646

Branch, M. C., Weber, M., Li, M. Y., Flora, P.#, & Ezhkova, E#. (2024). Overview of chromatin regulatory processes during surface ectodermal development and homeostasis. Developmental biology, 515, 30–45. https://doi.org/10.1016/j.ydbio.2024.07.001 (#co-corresponding authors)

Nguyen, M. B.*, Flora, P.*, Branch, M. C., Weber, M., Zheng, X. Y., Sivan, U., Joost, S., Annusver, K., Zheng, D., Kasper, M., & Ezhkova, E. (2024). Tenascin-C expressing touch dome keratinocytes exhibit characteristics of all epidermal lineages. Science advances, 10(3), eadi5791. https://doi.org/10.1126/sciadv.adi5791 (*co-first authors)

Flora, P., & Ezhkova, E. (2024). Cleavage Under Targets & Release Using Nuclease (CUT&RUN) of Histone Modifications in Epidermal Stem Cells of Adult Murine Skin. Methods in molecular biology (Clifton, N.J.), 2736, 9–21. https://doi.org/10.1007/7651_2023_499

2023

Weber, M., Nguyen, M. B., Li, M. Y., Flora, P., Shuda, M., & Ezhkova, E. (2023). Merkel Cell Polyomavirus T Antigen-Mediated Reprogramming in Adult Merkel Cell Progenitors. The Journal of investigative dermatology, 143(11), 2163–2176.e6. https://doi.org/10.1016/j.jid.2023.04.031

2021

Flora, P., Li, M. Y., Galbo, P. M., Jr, Astorkia, M., Zheng, D., & Ezhkova, E. (2021). Polycomb repressive complex 2 in adult hair follicle stem cells is dispensable for hair regeneration. PLoS genetics, 17(12), e1009948. https://doi.org/10.1371/journal.pgen.1009948

Flora, P.*, Dalal, G.*, Cohen, I., & Ezhkova, E. (2021). Polycomb Repressive Complex(es) and Their Role in Adult Stem Cells. Genes, 12(10), 1485. https://doi.org/10.3390/genes12101485 (*co-first authors)

Li, M. Y., Flora, P., Pu, H., Bar, C., Silva, J., Cohen, I., Galbo, P. M., Jr, Liu, H., Yu, X., Jin, J., Koseki, H., D'Orazio, J. A., Zheng, D., & Ezhkova, E. (2021). UV-induced reduction in Polycomb repression promotes epidermal pigmentation. Developmental cell, 56(18), 2547–2561.e8. https://doi.org/10.1016/j.devcel.2021.08.006

2020

Flora, P., & Ezhkova, E. (2020). Regulatory mechanisms governing epidermal stem cell function during development and homeostasis. Development (Cambridge, England), 147(22), dev194100. https://doi.org/10.1242/dev.194100

2018

Flora, P., Wong-Deyrup, S. W., Martin, E. T., Palumbo, R. J., Nasrallah, M., Oligney, A., Blatt, P., Patel, D., Fuchs, G., & Rangan, P. (2018). Sequential Regulation of Maternal mRNAs through a Conserved cis-Acting Element in Their 3' UTRs. Cell reports, 25(13), 3828–3843.e9. https://doi.org/10.1016/j.celrep.2018.12.007

Flora, P., Schowalter, S., Wong-Deyrup, S., DeGennaro, M., Nasrallah, M. A., & Rangan, P. (2018). Transient transcriptional silencing alters the cell cycle to promote germline stem cell differentiation in Drosophila. Developmental biology, 434(1), 84–95. https://doi.org/10.1016/j.ydbio.2017.11.014

2017

Flora, P., McCarthy, A., Upadhyay, M., & Rangan, P. (2017). Role of Chromatin Modifications in Drosophila Germline Stem Cell Differentiation. Results and problems in cell differentiation, 59, 1–30. https://doi.org/10.1007/978-3-319-44820-6_1

2016

Upadhyay, M., Martino Cortez, Y., Wong-Deyrup, S., Tavares, L., Schowalter, S., Flora, P., Hill, C., Nasrallah, M. A., Chittur, S., & Rangan, P. (2016). Transposon Dysregulation Modulates dWnt4 Signaling to Control Germline Stem Cell Differentiation in Drosophila. PLoS genetics, 12(3), e1005918. https://doi.org/10.1371/journal.pgen.1005918

bottom of page